The global Cryo Preservation Market size was valued at USD 9.5 billion in 2025 and is projected to expand at a compound annual growth rate (CAGR) of 11.8% during the forecast period, reaching a value of USD 23.1 billion by 2033.
MARKET SIZE AND SHARE
The global cryo preservation market is projected to grow significantly from 2025 to 2032, driven by advancing biotechnology and rising demand for cell therapies. Market share is concentrated among key players offering biostorage and cryogenic systems. Expanding applications in regenerative medicine and genetic material storage will fuel revenue expansion, with product segments like cryogenic tanks holding a dominant share of the overall market pie through the forecast period.
By 2032, the market's size will be shaped by increased investment in biobanking and fertility preservation. The competitive share landscape will see consolidation as large firms acquire niche specialists. North America currently commands a major revenue share, though Asia-Pacific regions are anticipated to gain share rapidly. Technological innovations in cryoprotectants and automated storage will be crucial for companies aiming to expand their market presence and capture a larger portion of future industry value.
INDUSTRY OVERVIEW AND STRATEGY
The cryo preservation industry encompasses the long-term storage of biological samples at ultra-low temperatures, serving pharmaceutical, clinical, and research sectors. It is a critical enabler for modern medicine, including IVF, stem cell therapy, and drug discovery. The market is characterized by stringent regulatory standards and high technical expertise requirements. Strategic focus is on maintaining sample integrity and viability over decades, which forms the core value proposition for service providers and equipment manufacturers in this specialized field.
Key strategies for growth include vertical integration, with companies expanding from equipment into full-service biostorage solutions. Partnerships with research institutions and pharmaceutical firms are essential for securing long-term contracts. Innovation strategy prioritizes developing vapor-phase storage systems to reduce contamination risks and implementing advanced monitoring software. Sustainability initiatives, like optimizing liquid nitrogen usage, also form a strategic differentiator to reduce operational costs and appeal to environmentally conscious clients in a competitive marketplace.
REGIONAL TRENDS AND GROWTH
North America leads the cryo preservation market, driven by strong R&D funding, advanced healthcare infrastructure, and high adoption of assisted reproductive technologies. Europe follows with significant biobanking initiatives and supportive regulatory frameworks. The Asia-Pacific region emerges as the fastest-growing area, fueled by increasing medical tourism for fertility treatments, rising healthcare expenditure, and growing biopharmaceutical sector. Each region exhibits distinct trends in adoption rates for clinical versus research applications.
Primary growth drivers include the expanding regenerative medicine pipeline and rising prevalence of chronic diseases requiring cell-based therapies. Major restraints are the high operational costs and complex regulatory compliance. Opportunities lie in emerging markets and technological advancements like cryopreservation without ice formation. Key challenges involve ethical concerns, sample security risks, and the need for standardized protocols across global regions to ensure consistency and reliability in long-term biological storage.
CRYO PRESERVATION MARKET SEGMENTATION ANALYSIS
BY TYPE:
The equipment segment holds a dominant share of the cryo preservation market due to the critical role of advanced freezing, storage, and monitoring systems in maintaining long-term biological viability. Continuous innovation in cryogenic freezers, automated storage systems, and temperature-controlled transport solutions has significantly enhanced preservation efficiency while reducing contamination and sample loss. Rising investments by hospitals, fertility clinics, and biobanks in high-capacity and automated equipment are driven by the growing volume of preserved biological samples and the need for regulatory compliance, traceability, and operational reliability.
The media and consumables segments collectively contribute a substantial and recurring revenue stream, supported by the repeated use of cryoprotective agents, freezing media, vials, straws, and storage containers. Cryo preservation media play a decisive role in protecting cellular integrity during freezing and thawing, particularly for sensitive samples such as stem cells and embryos. Consumables benefit from steady demand across clinical, research, and industrial applications, with growth reinforced by increasing procedure volumes, expansion of fertility services, and rising cell-based research activities worldwide.
BY APPLICATION:
Reproductive medicine represents one of the most mature and revenue-generating application segments, driven by the increasing prevalence of infertility, delayed parenthood, and growing acceptance of assisted reproductive technologies. Cryo preservation of sperm, oocytes, and embryos has become a standard clinical practice, supported by improving success rates and advancements in vitrification techniques. Fertility clinics across developed and emerging markets continue to expand their cryo storage capabilities, reinforcing long-term demand for preservation solutions.
The regenerative medicine, drug discovery, cell banking, and research segments are experiencing rapid growth due to the expanding role of cell-based therapies, personalized medicine, and advanced biomedical research. Cryo preservation enables long-term storage of critical cell lines and biological samples essential for clinical trials, therapeutic development, and translational research. Increasing funding for stem cell research, rising biobanking initiatives, and pharmaceutical companies’ focus on biologics and cell therapies are key factors accelerating adoption across these applications.
BY SAMPLE TYPE:
The human cells and stem cells segments account for a significant share of the market due to their extensive use in regenerative medicine, immunotherapy, and biomedical research. Stem cells, in particular, require precise preservation conditions to maintain viability and differentiation potential, making advanced cryo preservation techniques indispensable. Growing clinical applications of stem cell therapies and increasing cord blood banking initiatives are major contributors to sustained market growth within this segment.
The preservation of oocytes, embryos, sperm, and tissues is strongly driven by reproductive medicine and biobanking activities. Embryo and oocyte cryo preservation have gained widespread clinical acceptance due to improved freezing outcomes and regulatory support. Tissue preservation is increasingly utilized in oncology research, transplant medicine, and disease modeling, further diversifying the market. The rising volume of stored samples across fertility clinics and research institutions continues to expand the demand for reliable cryo preservation solutions across all sample types.
BY PRESERVATION METHOD:
Slow freezing remains widely used due to its established protocols, cost efficiency, and applicability across a broad range of cell types. This method is particularly prevalent in research laboratories and certain clinical applications where controlled cooling rates are essential. Despite longer processing times, slow freezing continues to be adopted in settings where standardized and well-validated procedures are prioritized over speed.
Vitrification has emerged as a rapidly growing preservation method, especially in reproductive medicine, due to its ability to minimize ice crystal formation and improve post-thaw survival rates. The technique’s effectiveness in preserving oocytes and embryos has led to widespread clinical adoption, particularly in fertility centers. Advancements in vitrification media and protocols continue to enhance outcomes, positioning this method as a preferred choice for high-value and sensitive biological samples.
BY END USER:
Hospitals and fertility clinics represent major end users, driven by increasing patient volumes, expanding reproductive services, and the integration of cryo preservation into routine clinical workflows. Fertility clinics, in particular, rely heavily on cryo storage to support in vitro fertilization procedures, fertility preservation programs, and long-term embryo storage. Continuous investments in infrastructure and compliance with regulatory standards further strengthen demand from these end users.
Biobanks, research institutes, and pharmaceutical & biotechnology companies are experiencing accelerated adoption due to the growing importance of sample integrity in research and drug development. Biobanks play a critical role in storing large volumes of biological materials for population studies and clinical research. Pharmaceutical and biotechnology companies increasingly depend on cryo preservation to support cell therapy manufacturing, clinical trials, and biologics development, making this segment a key driver of technological advancement and market expansion.
BY EQUIPMENT TYPE:
Cryogenic freezers dominate the equipment landscape due to their essential role in achieving precise temperature control and ensuring sample stability. Technological advancements such as automated temperature monitoring, alarm systems, and energy-efficient designs have enhanced their adoption across clinical and research settings. High-capacity freezers are particularly favored by biobanks and large research institutions managing extensive sample inventories.
Cryogenic storage systems and accessories support long-term preservation and operational efficiency, especially for large-scale storage requirements. Storage systems designed for liquid nitrogen environments enable ultra-low temperature maintenance over extended periods, while accessories such as racks, canisters, and monitoring devices improve organization and safety. Growing emphasis on sample traceability, automation, and space optimization continues to drive demand for advanced storage solutions and complementary accessories.
BY CRYOGEN:
Liquid nitrogen is the most widely used cryogen, owing to its ability to achieve extremely low temperatures, cost effectiveness, and widespread availability. Its extensive use across fertility clinics, hospitals, and biobanks makes it a cornerstone of cryo preservation practices. Continuous improvements in nitrogen storage and handling systems further enhance safety and operational efficiency, reinforcing its dominant market position.
Liquid helium and other cryogens serve niche applications where ultra-low temperatures beyond liquid nitrogen capabilities are required, particularly in advanced research and specialized industrial processes. While liquid helium usage is limited by higher costs and supply constraints, it remains essential for select scientific applications. Alternative cryogens and hybrid cooling technologies are gaining attention as institutions seek flexible and sustainable preservation solutions, contributing to gradual diversification within this segment.
RECENT DEVELOPMENTS
- In Jan 2024: Thermo Fisher Scientific launched the Revvity Signals Research platform, integrating cryostorage data management to enhance sample tracking and integrity for biobanks and research facilities.
- In Apr 2024: Merck KGaA expanded its cryopreservation media portfolio with a new, serum-free, animal origin-free formulation designed to improve post-thaw viability for cell and gene therapies.
- In Jul 2024: Azenta Life Sciences announced a major expansion of its automated, -20°C bio-storage facility in Boston, significantly increasing its capacity for managing critical research samples.
- In Nov 2024: Chart Industries completed the acquisition of Cryo Biotec, strengthening its position in the fertility and reproductive medicine segment of the cryogenic storage market.
- In Feb 2025: BioLife Solutions received FDA 510(k) clearance for its new evo® Cold Chain management system, a smart monitoring platform for shipped cryogenic containers.
KEY PLAYERS ANALYSIS
- Thermo Fisher Scientific Inc.
- Merck KGaA
- Avantor, Inc.
- BioLife Solutions, Inc.
- Azenta Life Sciences
- Chart Industries, Inc.
- Worthington Industries
- Linde plc
- Air Liquide S.A.
- Praxair Technology, Inc. (Linde)
- Corning Incorporated
- Nikkiso Co., Ltd.
- Cryologics
- Cryotherm
- Stirling Ultracold
- Custom Biogenic Systems
- Arctiko
- Labcold
- Hamilton Company
- Sanyo (Panasonic Biomedical)
